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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK1
All Species:
11.52
Human Site:
S380
Identified Species:
21.11
UniProt:
P57059
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P57059
NP_775490.2
783
84902
S380
E
V
P
Q
E
G
L
S
T
D
P
F
R
P
A
Chimpanzee
Pan troglodytes
XP_531484
783
84972
S380
E
V
P
Q
E
G
L
S
T
D
P
F
R
P
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_544912
898
97147
F505
F
E
V
T
Q
E
A
F
S
G
D
P
F
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q60670
779
85009
L382
L
E
V
P
Q
E
I
L
P
C
D
P
F
R
P
Rat
Rattus norvegicus
Q9R1U5
776
84890
L382
L
E
V
P
Q
E
I
L
P
C
D
P
F
R
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
L387
F
E
I
P
P
E
A
L
S
S
E
S
L
R
S
Chicken
Gallus gallus
Q9IA88
798
88848
T380
E
M
P
Q
D
S
L
T
S
E
T
L
R
S
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
S432
D
G
P
M
A
L
D
S
D
E
G
E
E
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
S764
Q
S
F
R
Y
K
M
S
A
E
A
S
K
L
F
Honey Bee
Apis mellifera
XP_397175
718
80391
A364
K
S
R
T
R
E
D
A
T
R
G
G
K
R
F
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
A590
S
S
Q
N
D
A
A
A
T
A
A
G
G
T
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
D161
R
C
N
I
K
I
A
D
F
G
L
S
N
V
M
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
L282
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
69.2
N.A.
81.3
81.6
N.A.
70.4
66.6
N.A.
32
N.A.
28.8
36.5
24.5
N.A.
Protein Similarity:
100
99.6
N.A.
73.6
N.A.
86.2
86.3
N.A.
77
76.6
N.A.
44
N.A.
38
50.9
39.4
N.A.
P-Site Identity:
100
100
N.A.
0
N.A.
0
0
N.A.
0
33.3
N.A.
20
N.A.
6.6
6.6
6.6
N.A.
P-Site Similarity:
100
100
N.A.
20
N.A.
13.3
13.3
N.A.
13.3
73.3
N.A.
40
N.A.
40
26.6
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41
42.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
16
16
31
16
8
8
16
0
0
0
16
% A
% Cys:
0
8
0
0
0
0
0
0
0
16
0
0
0
0
0
% C
% Asp:
8
0
0
0
16
0
16
8
8
16
24
0
0
0
0
% D
% Glu:
24
31
0
0
16
39
0
0
0
24
8
8
8
0
0
% E
% Phe:
16
0
8
0
0
0
0
8
8
0
0
16
24
0
16
% F
% Gly:
0
8
0
8
0
16
8
0
0
16
16
16
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
8
0
8
16
0
8
0
0
0
0
8
0
% I
% Lys:
8
0
0
0
8
8
0
0
0
8
0
0
16
0
0
% K
% Leu:
24
0
0
0
0
8
24
31
0
0
8
8
16
8
0
% L
% Met:
0
8
0
8
0
0
8
0
0
0
0
8
0
0
8
% M
% Asn:
0
0
8
8
0
0
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
0
39
24
8
0
0
0
16
0
16
24
0
24
16
% P
% Gln:
8
0
8
24
24
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
8
8
8
0
0
0
0
8
8
0
24
39
0
% R
% Ser:
8
31
0
0
0
8
0
31
24
8
0
24
0
8
31
% S
% Thr:
0
0
0
16
0
0
0
8
31
0
8
0
0
8
0
% T
% Val:
0
16
24
0
0
0
0
0
0
0
0
0
0
8
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _